Managing hypertension requires a multi-faceted approach, and for those seeking complementary strategies, understanding the role of weight management is crucial. The best diet pills for high blood pressure are designed to assist in this endeavor, targeting metabolic pathways and appetite regulation.
Navigating the market for these specialized supplements, or effective weight loss aids, demands a nuanced understanding of ingredient efficacy and potential contraindications. Consumers often seek these best diet pills for high blood pressure to complement lifestyle changes, aiming for a synergistic effect on both weight reduction and cardiovascular well-being. Delving into the science behind appetite suppressants and metabolism boosters reveals intricate biochemical processes.
If you’re exploring options to support your health goals, understanding these advancements is paramount. Learn which formulations are emerging as leading choices for individuals concerned about blood pressure alongside weight management.
Your Best Choices for High Blood Pressure Support
1. Beet Root 5-in-1 Complex Capsules – Healthy Blood Pressure Support
Unlock a healthier you with the NUTRAHARMONY Beet Root 5-in-1 Complex Capsules. Specifically formulated to support cardiovascular wellness, these capsules offer a potent blend to invigorate your circulation, boost energy, and promote overall vitality for an active, balanced lifestyle.
Experience the concentrated power of beet root with an extra strength 20:1 extract, delivering 500 mg per serving in an easy-to-swallow capsule. This comprehensive formula also includes Olive Leaf, Hibiscus, Garlic Extract, and Hawthorn Berry, working synergistically to support healthy blood pressure and enhance blood flow naturally.
Pros
- Supports Healthy Blood Pressure: Carefully crafted to help maintain blood pressure already within a normal range, contributing to a healthier cardiovascular system.
- Enhanced Circulation and Energy: The combined power of beet root and supporting botanicals promotes better blood flow, oxygen delivery, and sustained daily energy levels.
- Comprehensive 5-in-1 Formula: A unique blend of Beet Root, Olive Leaf, Hibiscus, Garlic Extract, and Hawthorn Berry provides multifaceted wellness support in a single, convenient supplement.
- Premium Quality and Purity: Manufactured in the USA in GMP-certified facilities and third-party tested, ensuring a high standard of purity and potency for reliable health benefits.
Cons
- Effectiveness may vary for individuals, as with any natural supplement aimed at supporting blood pressure within normal ranges, and should be used as part of a healthy lifestyle.
For those seeking natural ways to support their heart health and circulation, the NUTRAHARMONY Beet Root 5-in-1 Complex offers a robust, plant-based solution. It’s an excellent choice for adults looking for daily wellness support, whether for active routines or simply aiming for a more balanced and energetic life.
2. Qunol Blood Pressure Support, 3 in 1 Beets + CoQ10
Support a robust cardiovascular system with Qunol Blood Pressure Support, a powerful 3-in-1 complex designed to help maintain healthy blood pressure levels. This carefully crafted formula leverages the natural power of beet root, CoQ10, and grape seed extract for comprehensive heart health and circulation support.
Qunol’s 3-in-1 Blood Pressure Support capsules combine the potent benefits of beet root, a rich source of natural nitrates, with the antioxidant power of CoQ10 for vascular health and heart energy. The inclusion of grape seed extract, clinically shown to support blood pressure within a normal range, makes this a complete solution for cardiovascular wellness and improved circulation.
Pros
- Offers a synergistic 3-in-1 formula featuring beet root, CoQ10, and grape seed extract, providing multiple avenues of cardiovascular support.
- Leverages natural nitrates from beet root, known for their role in promoting healthy blood flow and blood pressure regulation.
- Contains CoQ10, a crucial antioxidant that aids in vascular health and supports cellular energy production for your heart.
- Includes grape seed extract, specifically highlighted for its clinical evidence in supporting blood pressure levels already in the normal range and overall cardiovascular function.
- From Qunol, the #1 brand of CoQ10, ensuring a trusted and high-quality supplement for supporting heart health and circulation.
Cons
- As with any supplement, individual results may vary, and it’s recommended to consult with a healthcare professional, especially if you have pre-existing health conditions or are taking medication.
For individuals seeking natural support for cardiovascular function and healthy blood pressure, Qunol Blood Pressure Support offers a well-rounded approach. This vegetarian-friendly supplement is an excellent choice for those looking to enhance their heart health through a synergistic blend of scientifically-backed ingredients.
3. PurePremium Blood Pressure Supplements with Hawthorn Berry, Hibiscus, Garlic &
Discover a natural pathway to maintaining healthy blood pressure levels with PurePremium Blood Pressure Supplements. This expertly crafted formula leverages potent herbal extracts and essential vitamins to support your cardiovascular health and promote normal nitric oxide production, contributing to your overall well-being.
PurePremium’s advanced herbal blend is designed for optimal absorption, offering a fast-acting solution to support cardiovascular health. As a comprehensive, all-in-one dietary supplement, it aims to assist individuals in managing normal blood pressure and encouraging healthy circulation, making it a valuable addition to your daily wellness regimen.
Pros
- Supports Normal Blood Pressure: Contains a synergistic combination of hawthorn berry, hibiscus, garlic extract, and other herbs known for their beneficial effects on maintaining blood pressure within a healthy range.
- Enhances Nitric Oxide Production: Formulated to support normal nitric oxide levels, which is crucial for healthy blood flow and overall cardiovascular function, setting it apart from generic circulation support supplements.
- Comprehensive Nutrient Blend: Features a wide array of beneficial ingredients including Vitamin C, Niacin, Vitamin B6, Folate, Vitamin B12, olive leaf, buchu leaf, uva ursi, juniper berry, and green tea extract for holistic support.
- USA-Made & Lab Tested: Manufactured in a stringent, USA-based facility and verified by third-party labs to ensure purity, potency, and safety, offering peace of mind for supplement buyers.
- Gluten-Free Formula: Suitable for individuals with gluten sensitivities, this blood pressure support supplement fits seamlessly into various dietary preferences.
Cons
- Consultation Required for Certain Users: As with any dietary supplement, it’s essential to consult a healthcare professional before use, especially if you have pre-existing medical conditions or are taking prescription medications for hypertension or other ailments.
For those seeking to naturally support their blood pressure and boost nitric oxide for better circulation, PurePremium Blood Pressure Supplements offer a well-rounded and trustworthy option. Incorporate these daily capsules into your routine to contribute positively to your cardiovascular wellness journey.
4. Heart Health Blood Pressure Support Supplement – Support Blood Pressure
Struggling with elevated blood pressure levels and seeking a natural way to support cardiovascular wellness? Discover the Heart Health Blood Pressure Support Supplement, a meticulously crafted formula designed to promote healthy circulation and contribute to a balanced lifestyle.
This supplement focuses on nurturing your circulatory system for overall better heart health.
This advanced supplement harnesses the power of natural herbs and essential vitamins to help improve blood circulation, thereby supporting healthy blood pressure (BP) and fluid blood flow. It’s formulated with ingredients known for their cardiovascular benefits, aiming to assist your body in maintaining optimal heart function and cholesterol balance.
Pros
- Promotes Healthy Circulation & Blood Pressure: Contains hawthorn berry extract, olive leaf, green tea leaf, and garlic powder, ingredients traditionally recognized for their ability to support a healthy cardiovascular system and enhance blood circulation, contributing to natural blood pressure management.
- Supports Overall Heart Health: Enriched with heart vitamins, this formula goes beyond BP support to foster general cardiovascular well-being, aiding your body in maintaining a healthy heart.
- Cholesterol Balancing Support: The herbal blend is designed to assist in maintaining healthy cholesterol levels within a normal range, a crucial aspect of comprehensive heart care.
- High-Quality & USA Made: Manufactured in GMP-certified facilities in the USA, this Non-GMO supplement adheres to stringent quality and safety standards, assuring consumers of its integrity.
- Comprehensive Formula: Includes a blend of Niacin, Folic Acid, Buchu Leaf, Vitamin B-12, Folate, and Hibiscus, creating a well-rounded nutritional approach for BP and heart health.
- Risk-Free Purchase: Backed by an exceptional 120-day money-back guarantee, offering complete buyer confidence and peace of mind.
Cons
- As with any dietary supplement, individual results may vary, and it’s advisable to consult a healthcare professional before starting any new regimen, especially if you have pre-existing health conditions or are taking medication for high blood pressure.
For individuals seeking natural support for their blood pressure and cardiovascular health, the Heart Health Blood Pressure Support Supplement offers a promising, high-quality option. Its robust ingredient profile and commitment to quality make it a compelling choice for those aiming to maintain healthy BP and a strong heart.
5. Force Factor Total Beets Blood Pressure Support Beet Root Capsules,
Support your cardiovascular well-being with Force Factor Total Beets, a powerful dietary supplement designed to promote healthy blood pressure levels and optimize circulation. Experience the natural benefits of organic beet root and hawthorn berry in a convenient, high-potency capsule for daily use.
Each serving delivers a substantial 1800mg of organic beet root powder, paired with hawthorn berry, to actively contribute to your daily heart health regimen. This advanced formula also includes a clinically proven grape seed extract, researched for its ability to support blood pressure management beyond diet and exercise alone.
Pros
- High-Potency Organic Beet Root: Each capsule is packed with 1800mg of organic beet root powder, a key ingredient recognized for its nitric oxide boosting properties, crucial for healthy blood flow and circulation support.
- Clinically Supported Blood Pressure Management: Features a science-backed grape seed extract demonstrated to offer superior blood pressure support compared to lifestyle changes alone, making it a potent addition to your wellness routine.
- Enhanced Blood Circulation & Oxygen Delivery: Formulated to increase nitric oxide levels, promoting better blood flow throughout the body. This aids in delivering vital oxygen and nutrients to your heart and every cell for improved overall vitality.
- USA-Made Quality & Purity: Proudly manufactured in GMP-certified facilities within the United States, guaranteeing stringent quality control and ensuring the potency and purity of every ingredient through rigorous third-party testing.
- America’s Leading Beet Brand: Force Factor leverages cutting-edge research to create innovative beet-based supplements, establishing itself as the number one brand for beet-focused health products nationwide.
Cons
- While effective for many, individual results regarding blood pressure support can vary, and this supplement is not a substitute for prescribed medications or a doctor’s advice.
Force Factor Total Beets offers a convenient and potent way to support your cardiovascular health, focusing on natural ingredients known for their circulatory benefits. For individuals seeking to bolster their heart health and improve blood flow, these beet root capsules provide a science-backed, USA-manufactured solution. It stands out as a top choice for those prioritizing beet-based supplements within the heart health and circulatory support category.
6. Garlique Garlic Extract Supplement, Healthy Blood Pressure Formula, Odorless &
Unlock a healthier cardiovascular path with Garlique Garlic Extract Supplement. This advanced formula is expertly crafted to support healthy blood pressure levels naturally, offering a potent blend of garlic’s beneficial allicin combined with essential vitamins and minerals for comprehensive heart support.
Garlique features a unique blend designed for cardiovascular support, incorporating clinically studied allicin from garlic alongside vital nutrients like Vitamin C, B6, B12, Magnesium, and Folic Acid. This synergistic combination aims to assist in maintaining healthy blood pressure, promoting overall well-being without the harshness of drugs.
Pros
- Targeted Blood Pressure Support: Clinically supported levels of allicin, the active compound in garlic, are scientifically recognized for their role in cardiovascular health and promoting healthy blood pressure ranges.
- Enriched Nutrient Profile: Fortified with Vitamins C, B6, and B12, plus Magnesium and Folic Acid, this supplement goes beyond garlic to offer a more complete nutritional approach to heart health.
- Odorless & Easy to Take: Users appreciate that Garlique is an odorless garlic supplement, eliminating the common drawback associated with garlic consumption and making it a convenient caplet to incorporate into daily routines.
- Trusted & Long-Standing Brand: With over 25 years of expertise, Garlique is a reliable, drug-free choice for those seeking to manage cholesterol, blood pressure, and blood sugar levels, manufactured with rigorous quality standards in the USA.
- Dietary Friendly: This formula is Gluten-free, Non-GMO, Vegan friendly, and Soy free, making it suitable for a wide range of dietary preferences and restrictions, free from sugar, starch, artificial flavors, caffeine, dairy, or preservatives.
Cons
- While effective for many, results can vary; individuals with specific medical conditions should always consult with their healthcare provider before starting any new supplement regimen.
For those seeking a natural approach to managing their cardiovascular health, especially focusing on maintaining healthy blood pressure, Garlique presents a well-rounded and trustworthy option. Its blend of potent garlic extract and essential nutrients, combined with its commitment to quality and dietary accessibility, makes it a standout choice for daily wellness routines.
7. humanN SuperBeets Heart Chews, Beet Root Powder Support Energy Supplement,
Elevate your cardiovascular wellness and energy levels with humanN SuperBeets Heart Chews. These delicious pomegranate berry flavored soft chews are expertly formulated with clinically studied ingredients to champion healthy blood pressure, enhance circulation, and boost your daily vitality, offering a convenient path to a healthier heart.
Harness the power of plant-based nutrition, featuring a robust blend of Grape Seed Extract and beetroot powder. Optimized to support nitric oxide levels, these heart health supplements deliver tangible benefits for circulation and energy, all within a non-GMO, gluten-free chew designed for adults seeking comprehensive cardiovascular support and overall well-being.
Pros
- Supports healthy blood pressure management with clinically validated Grape Seed Extract, contributing to optimal cardiovascular function.
- Boosts energy and supports healthy circulation by enhancing nitric oxide production, essential for overall vitality.
- Convenient, individually wrapped soft chews in a tasty pomegranate berry flavor make consistent intake effortless for busy lifestyles, serving as an on-the-go heart health solution.
- Formulated with plant-based, non-GMO ingredients including USA-grown beetroot supplement powder and French Grape Seed Extract, catering to health-conscious consumers.
- These beetroot chews offer antioxidant support and actively contribute to cardiovascular health beyond basic dietary intake.
Cons
- While designed for convenience, some users might prefer a liquid or capsule format for their dietary supplements routine.
humanN SuperBeets Heart Chews offer a scientifically backed, palatable approach to enhancing heart health and combating fatigue. Ideal for adults seeking a natural way to support blood pressure and circulation, these chews integrate seamlessly into any daily regimen, providing powerful nutrition in a simple, enjoyable format.
8. Force Factor Total Beets Ultimate Heart Health, Beet Root Capsules
Unlock your heart’s full potential with Force Factor Total Beets Ultimate Heart Health, a powerful blend designed to support cardiovascular wellness and enhance circulation. This advanced formula leverages the natural power of beet root and science-backed ingredients for comprehensive heart health support.
Experience a high-potency capsule featuring 1,800mg of beet root, infused with CoQ10, MegaNatural-BP grapeseed extract, hawthorn, and hibiscus. This synergistic mix is crafted to deliver superior blood pressure support, promote improved circulation, and provide energy without reliance on stimulants.
Pros
- Superior Blood Pressure Support: Formulated with a clinically studied grapeseed extract, proven to offer up to 2X better blood pressure management than diet and exercise alone, contributing to healthy blood pressure levels.
- Enhanced Circulation and Blood Flow: Rich in nitric oxide precursors from beet root, this supplement actively supports improved blood flow, ensuring optimal oxygen and nutrient delivery to your heart and vital organs.
- Energy Without Jitters: Combines beet root, CoQ10, and B vitamins to naturally boost heart-healthy energy production and support overall cardiovascular function, helping you feel energized throughout the day.
- Premium, Tested Ingredients: Features a potent blend of 1,800mg beet root, 100mg CoQ10, MegaNatural-BP grapeseed, hawthorn, and hibiscus, all third-party tested for potency and purity.
- Quality Manufacturing: Proudly made in the USA in GMP-compliant facilities, ensuring the highest standards of quality and safety for your peace of mind.
Cons
- While designed for broad heart health, individuals managing specific diagnosed conditions should always consult their healthcare provider before incorporating new supplements, especially if seeking alternatives to prescribed medications or looking for the best diet pills for high blood pressure as a sole solution.
Force Factor Total Beets Ultimate Heart Health offers a comprehensive approach to bolstering your cardiovascular system. Its robust formula makes it an excellent choice for those seeking natural support for healthy blood pressure and enhanced circulation as part of an active lifestyle.
9. Sunergetic Premium Blood Pressure Support Supplement for Cardiovascular & Heart
Unlock optimal cardiovascular wellness with Sunergetic Premium Blood Pressure Support, a carefully formulated supplement designed to help maintain healthy blood pressure levels already within the normal range. Discover a powerful blend of natural herbs and essential vitamins engineered to promote heart health and robust circulation, empowering you to feel your best.
This advanced formula contributes to cardiovascular well-being by incorporating well-regarded ingredients known for their supportive properties. Featuring a comprehensive mix of vitamins and botanical extracts, this supplement aims to provide holistic heart support, assisting in the maintenance of healthy blood pressure as part of a balanced lifestyle. Take 1 to 3 capsules daily to support your circulatory system and overall vitality.
Take 1 to 3 capsules daily to support your circulatory system and overall vitality.
Pros
- Comprehensive Cardiovascular Support: Formulated with a synergistic blend of herbs like Hawthorn, Hibiscus, and Olive Leaf, alongside essential vitamins (C, B6, Folate, B12) and Niacin, to contribute to cardiovascular health and support healthy blood pressure levels already within the normal range.
- Promotes Healthy Circulation: Ingredients such as Garlic and Green Tea Extract are included to aid in promoting healthy blood flow and circulation throughout the body, helping you feel more energetic and vital.
- High-Quality and USA-Made: Manufactured in the USA in a facility adhering to Good Manufacturing Practices, with stringent third-party testing for potency, heavy metals, and microbes, ensuring a premium and trustworthy product.
Cons
- Requires Consistent Use: As with most dietary supplements, noticeable benefits for maintaining healthy blood pressure levels will likely require consistent, daily intake as directed over an extended period.
Sunergetic Premium Blood Pressure Support offers a scientifically crafted approach to nurturing your cardiovascular system. If you are seeking a natural supplement to complement your healthy lifestyle and support already normal blood pressure, this blend of potent herbs and vitamins is an excellent choice, backed by a strong satisfaction guarantee.
10. Qunol Beets Chews for Blood Pressure Support, 3 in 1
Discover a delicious and convenient way to support healthy blood pressure with Qunol Beets Chews. This unique 3-in-1 formula combines the power of beets, CoQ10, and Grape Seed extract to promote cardiovascular wellness and healthy circulation. Experience a natural approach to maintaining blood pressure within the normal range with these vegetarian soft chews.
Qunol Beets Chews are expertly formulated to assist in maintaining blood pressure levels that are already within a normal range, offering a natural boost from beet-derived nitrates. The inclusion of Coenzyme Q10, a potent antioxidant, supports energy production and vascular health, while Grape Seed extract is clinically recognized for its blood pressure supporting properties. Enjoy the juicy berry flavor as you nourish your heart health.
Pros
- Supports Healthy Blood Pressure: Specifically designed to help maintain blood pressure within a normal range, leveraging natural nitrates from beets and clinically proven Grape Seed extract.
- 3-in-1 Powerhouse Formula: Combines three key ingredients – beets, CoQ10, and Grape Seed – for comprehensive cardiovascular and circulatory support, promoting overall heart health.
- Delicious and Convenient: Offered in a tasty vegetarian soft chew with a juicy berry flavor, making it an easy and enjoyable addition to your daily wellness routine for managing blood pressure.
- Antioxidant and Energy Support: Features Coenzyme Q10, a vital antioxidant that also aids in cellular energy production and supports vascular health, contributing to better circulation.
Cons
- Results may vary as this product is intended to support healthy blood pressure levels already within a normal range and is not a substitute for medical treatment.
For individuals seeking a natural way to bolster their cardiovascular health and manage blood pressure, Qunol Beets Chews offer a compelling, science-backed solution. Embrace the synergistic benefits of beets, CoQ10, and Grape Seed extract in a delightful chewable format for optimal heart and circulation support.
How to Choose Diet Pills for High Blood Pressure
Ingredient transparency and safety
A product’s ingredient makeup is paramount, particularly for individuals managing cardiovascular health, so scrutinizing what you ingest is essential.
Understanding the primary active compounds is your first step; for example, some popular thermogenics might contain stimulants like caffeine, while others employ appetite suppressants or metabolism boosters. Beyond the headline ingredients, critically examine the inactive components. Many formulations utilize fillers, binders, or artificial sweeteners that could potentially trigger adverse reactions or interact with prescribed medications.
Many formulations utilize fillers, binders, or artificial sweeteners that could potentially trigger adverse reactions or interact with prescribed medications. It is vital to investigate whether a supplement has undergone independent third-party testing, indicated by certifications from reputable organizations, which verifies potency and purity claims, offering a crucial layer of assurance regarding product integrity.
Furthermore, be aware of the distinction between natural plant extracts and synthetic compounds, as their bioactivity and potential side effects can differ significantly. For those monitoring blood pressure, carefully research any potential contraindications; ingredients like ephedra, synephrine, or even high doses of certain herbs can elevate heart rate and blood pressure.
Always consult your healthcare provider to discuss any potential interactions or risks associated with specific supplements before incorporating them into your regimen.
Impact on blood pressure and cardiovascular health
Prioritizing cardiovascular well-being necessitates understanding how weight management aids in blood pressure control.
Any dietary supplement designed to support individuals with elevated blood pressure must be scrutinized for its impact on the circulatory system. Ingredients that can either beneficially influence blood pressure through natural mechanisms, such as magnesium or potassium, or detrimentally elevate it need careful consideration.
Furthermore, these compounds should ideally complement a holistic approach to heart health, working synergistically with regular exercise, a balanced diet, and stress management techniques, rather than acting in isolation.
When evaluating products, look beyond superficial promises. Some formulations may contain components like guarana or synephrine, which are known stimulants and can be problematic for those monitoring their blood pressure.
Conversely, ingredients that support metabolism and contribute to a healthy weight can be highly beneficial, as shedding even a small amount of excess weight often leads to lower blood pressure. It is essential to distinguish between established pharmacological effects and anecdotal assertions. The ultimate goal is to find a supportive aid that aligns with a heart-conscious lifestyle and demonstrably contributes to overall vascular function and circulatory health.
Formulation and dosage effectiveness
The effectiveness of any weight management supplement hinges significantly on its precise formulation and how your body utilizes its active compounds.
Understanding the recommended daily dosage and frequency is paramount to achieving desired results while mitigating risks. This isn’t a one-size-fits-all scenario. Factors like ingredient bioavailability and absorption rates directly influence how much of a compound actually enters your bloodstream to exert its intended effects.
For instance, some nutrients are fat-soluble and require co-ingestion with a meal to maximize uptake, while others may be better absorbed on an empty stomach.
Consider whether the supplement employs time-release or immediate-release mechanisms. Time-release capsules can provide a more sustained effect throughout the day, potentially reducing the need for multiple doses, whereas immediate-release formulations offer a quicker onset of action.
Always consult with a healthcare professional to ensure the chosen product aligns with your individual health profile and will not interfere with your blood pressure management plan.
Quick Best Diet Pills For High Blood Pressure Buying Checklist
- Consult Your Doctor: Always speak with a healthcare professional before starting any new supplement, especially if you have high blood pressure.
- Ingredient Research: Thoroughly investigate all active and inactive ingredients for potential adverse effects on blood pressure.
- Blood Pressure Impact: Prioritize supplements with ingredients known not to negatively affect or potentially support cardiovascular health.
- Dosage Adherence: Understand and follow the recommended dosage instructions precisely.
- Reputable Brands: Choose products from established brands with transparent manufacturing practices and third-party testing.
- Holistic Approach: Remember that diet pills are most effective as part of a balanced diet, exercise, and medical treatment plan.
Frequently Asked Questions
Can Diet Pills Help With High Blood Pressure?
While diet pills can aid in weight management, which may positively influence blood pressure, they should not be seen as a direct treatment for hypertension. Always consult your doctor first.
What Ingredients Should I Avoid In Diet Pills If I Have High Blood Pressure?
Avoid ingredients known to elevate blood pressure, such as high levels of caffeine, ephedra, or other stimulants. Always check with your physician.
Are Natural Diet Pills Safe For High Blood Pressure?
Natural does not always mean safe. Some natural ingredients can still affect blood pressure. Research each ingredient and consult your doctor.
How Can I Choose A Diet Pill That Is Safe For My Condition?
Look for transparency in ingredients, third-party testing, and formulations that are not stimulants. Prioritize products recommended or approved by healthcare professionals.
Should I Inform My Doctor About The Diet Pills I’M Taking?
Absolutely. It is crucial to inform your doctor about any supplement you take, especially if you have high blood pressure, to avoid harmful interactions and ensure proper monitoring.
Final Words
Choosing the best diet pills for high blood pressure requires careful consideration of ingredients and effects on your cardiovascular health. Prioritizing safety, transparency, and professional advice ensures you find a supportive option. Start your weight management journey wisely and consult your doctor to safely achieve your health goals.
Start your weight management journey wisely and consult your doctor to safely achieve your health goals.